What is the dosage for citalopram?

  • The usual starting dose is 20 mg in the morning or evening. The dose may be increased to 40 mg daily after one week.
  • A dose of 60 mg has not been shown to be more effective than 40 mg.
  • As with all antidepressants, it may take several weeks of treatment before maximum effects are seen.
  • Doses are often slowly adjusted upwards to find the most effective dose.

Which drugs or supplements interact with citalopram?

Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor’s recommendation.


All SSRIs, including citalopram, should not be taken with any of the mono-amine oxidase (MAO) inhibitor-class of antidepressants, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane). Such combinations may lead to confusion, high blood pressure, tremor, and hyperactivity.

If treatment is to be changed from citalopram to an MAOI or vice-versa, there should be a 14 day period without either drug before the alternative drug is started. Tryptophan, a common dietary supplement, can cause headaches, nausea, sweating, and dizziness when taken with any SSRI. Linezolid and intravenous methylene blue are also MAO inhibitors and should not be combined with citalopram.

Pain Medications and NSAIDs

Use of an SSRI with aspirin, nonsteroidal anti-inflammatory drugs or other drugs that affect bleeding may increase the likelihood of upper gastrointestinal bleeding.

Severe interactions of citalopram include:

  • dronedarone
  • goserelin
  • isocarboxazid
  • leuprolide
  • phenelzine
  • pimozide
  • procarbazine
  • selegiline
  • selegiline transdermal
  • tranylcypromine
  • ziprasidone

Citalopram has serious interactions with at least 79 different drugs.

Citalopram has moderate interactions with at least 208 different drugs.

Mild interactions of citalopram include:

The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.

It is important to always tell your doctor, pharmacist, or health care provider of all prescription and over-the-counter medications you use, as well as the dosage for each, and keep a list of the information. Check with your doctor or health care provider if you have any questions about the medication. 

What else should I know about citalopram?

Do I need a prescription for citalopram?

Yes, a prescription is needed.

What preparations of citalopram are available?

Tablets: 10, 20, and 40 mg. Solution: 10 mg/5 ml

How should I keep citalopram stored?

Citalopram should be stored at room temperature, 15 to 30 C (59 to 86 F).